Intravenous immunoglobulin or intravenous lipid emulsion therapy in patients with elevated NK cytotoxicity improves live birth rates in different ways

Abstract

Problem: Many studies have demonstrated the negative impact of high rates of NK cytotoxicity (NKc) on reproductive outcomes, as well as the beneficial effects of intravenous immunoglobulin or intravenous lipid emulsion, specifically in these patients. Method of study: NKc was measured in PBMCs against K562 by flow cytometry. For retrospective analysis, 2250 cycles of ET were selected and divided into 4 groups according to NKc levels and treatment: normal (nNKc, n=587), elevated (eNKc, n=615), eNKc with IvIg treatment (n=231), and eNKc with IL treatment (n=180). Patients were <36 years old, negative for anticardiolipin antibodies, and did not have insufficient endometrium, thrombotic disorders, uterine abnormalities, or obesity. Patients aged 36-39 years (n=359) and 39-42 years (n=279) were analyzed separately using a similar approach.