Changes in the microbiota of the genital tract and intestines in patients with adenomyosis and infertility

Abstract

Introduction: Inflammation of the genital tract caused by a bacterial infection can affect the frequency of occurrence of hyperproliferative formations of the uterus, which in turn can lead to infertility. Changes in the microbiota of the vagina and intestines contribute to the formation of critical problems for women’s reproductive health. Material and methods: Microbiota composition was studied using microscopic and cultural bacteriological methods in genitalia and intestines in 64 women with adenomyosis and infertility and 30 healthy women. Results: The obtained results indicate that the microbiota of the genital tract in patients with adenomyosis and infertility is characterized by a different frequency of pathological manifestations (bacterial vaginosis, vaginitis, intermediate type of microbiocenosis) and excessive proliferation of vaginosis-associated microorganisms. Associative forms of bacterial contamination of the genital tract are registered in sick women. The formation of pathological intestinal microbiota in patients is largely due to a violation of the ratio between potentially pathogenic and protective species of bacteria. Conclusions: In women with adenomyosis and infertility, a pathological microbiota of the genital tract is formed, which is characterized by an increase in the structure of vaginal bacteria of representatives of pathogenic aerobic and vaginosis-associated microorganisms, a deficiency of lactobacilli. Intestinal microbiota in patients is characterized by the formation of multicomponent associations, which with a significant frequency contain conditionally pathogenic microorganisms.