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dc.contributor.authorЧіокадзе, М.-
dc.contributor.authorБар, К.-
dc.contributor.authorПастущек, Я.-
dc.contributor.authorДонськой, Б.В.-
dc.contributor.authorХажиленко, К.Г.-
dc.contributor.authorШлебнер, Е.-
dc.contributor.authorМаркерт, У.Р.-
dc.date.accessioned2021-03-03T20:02:01Z-
dc.date.available2021-03-03T20:02:01Z-
dc.date.issued2020-08-29-
dc.identifier.urihttp://dspace-ipag.com.ua/jspui/handle/123456789/176-
dc.description.abstractChanges in the number and cytotoxic potential of uterine Natural Killer (uNK) cells have been associated with reduced fertility. To provide a better characterization of immunophenotypes in the endometrium of women with uRPL (unexplained recurrent pregnancy loss), we examined the applicability of a set of five immune cell markers. The concentration (cells/mm 2 ) of CD45 + leukocytes, CD56 + uNK cells, and CD138 + plasma cells as well as of CD16 + and CD57 + cells, which indicate high cytotoxic uNK cells, were assessed by immunohistochemistry in endometrial biopsies from 61 uRPL patients and 10 controls. Control fertile endometria presented 90–300 CD56 + uNK cells/mm 2 . uRPL cases were classified in subgroups of low (uRPL-CD56 low < 90 cells/mm 2 ), normal (uRPL-CD56 normal 90–300 cells/mm 2 ), and high uNK cell counts (uRPL-CD56 high > 300 cells/mm 2 ). Some cases from the uRPL-CD56 low and uRPL-CD56 normal subgroups showed elevated proportions of cytotoxic CD16 + and CD57 + cells in relation to CD56 + cells. In the uRPL-CD56 high subgroup, the CD57/CD56 ratio was reduced in most samples and the CD16/CD56 ratio was unaltered. Analysis of CD138 excluded the influence of chronic endometritis on these observations. Our results reinforce a link between uRPL and a dysfunctional endometrial environment associated with distinct immune cell profiles.uk_UA
dc.language.isoenuk_UA
dc.publisherMDPIen
dc.relation.ispartofseriesdoi;10.3390/diagnostics10090650-
dc.subjectHuman; endometrium; recurrent pregnancy loss; natural killer cells; CD16; CD45; CD56; CD57; CD138uk_UA
dc.titleBeyond Uterine Natural Killer Cell Numbers in Unexplained Recurrent Pregnancy Loss: Combined Analysis of CD45, CD56, CD16, CD57, and CD138uk_UA
dc.typeOtheruk_UA
Располагается в коллекциях:Лабораторія імунології



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