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Хламідійна інфекція у жінок Київської області

Tue, 16 Mar 2021 00:00:00 GMT

Название: Хламідійна інфекція у жінок Київської області Авторы: Горбань, Н.Є. Краткий осмотр (реферат): TORCH-інфекції, за результатами генетичного моніторингу (1999-2003 рр.) у Київській області, були визначені пріоритетними чинниками ризику виникнення репродуктивних втрат генетичної етіології. Відтоді на базі КЗ КОР «КОЦОЗМіД» проводиться обстеження жінок репродуктивного віку з метою виявлення цих інфекцій та їх подальшого лікування. Однією з найпоширеніших є хламідійна інфекція (ХІ), яка ускладнює настання та перебіг вагітності, може призвести до порушення її розвитку, передчасних пологів та мати вплив на здоров’я дитини. Тому метою даної роботи було оцінити поширеність ХІ в Київській області серед жінок. Захворюваність жінок на ХІ розраховувалась на 1000 жінок 18 і старше років за даними МОЗ України за 2010-2017 рр. Також аналізувалась частота ХІ серед вагітних з обтяженим гінекологічним анамнезом, які звернулися за допомогою до КЗ КОР «КОЦОЗМіД» за цей же період. Лабораторні дослідження на ХІ проводилось із застосуванням імуноферментного аналізу з послідовним визначенням рівнів концентрацій сироваткових антитіл класу IgA та IgG за допомогою тест системи DIA-Chlamidia (ЧАО «НПК» ДИАПРОФ-МЕД). У 2010-2017 рр. захворюваність жінок на ХІ в Київській області була вищою ніж загальноукраїнський показник (1,92±0,02 проти 0,79±0,01‰). Окрім того, якщо в області у 2014-2017 порівняно з 2010-2013 рр. захворюваність на ХІ зросла з 1,83±0,02 до 2,01±0,03‰ (р<0,001), то в Україні зменшилась з 0,91±0,01 до 0,65±0,01‰ (р<0,001). У 29,82±1,01% вагітних жінок з обтяженим гінекологічним анамнезом були виявлені позитивні значення рівнів концентрації антитіл класу IgG, а у 21,31±1,04% – IgA. При цьому у 2014-2017 порівняно з 2010-2013 рр. відмічалося зростання частки вагітних з позитивними значеннями IgG (з 28,72±1,11 до 34,54±2,41%, р=0,03), тоді як для результатів щодо IgA частота суттєво не змінилася (20,72±1,17 проти 23,22±2,21% відповідно, р=0,34). Зафіксоване в Київській області зростання захворюваності на ХІ серед жінок потребує більш глибокого вивчення частоти такої патології серед інших категорій жінок та аналізу інших TORCH-інфекцій.

RESEARCH OF CONSUMPTION OF LOW-ALCOHOL BEVERAGES BY CHILDREN AND ADOLESCENTS IN UKRAINE

Sat, 21 Aug 2021 00:00:00 GMT

Название: RESEARCH OF CONSUMPTION OF LOW-ALCOHOL BEVERAGES BY CHILDREN AND ADOLESCENTS IN UKRAINE Авторы: Луценко, О.Г. Краткий осмотр (реферат): Since the early 1990s, the problem of alcohol consumption (hereinafter - AC) among adolescents and young people has become relevant, which was confirmed by the results of studies conducted by WHO in different countries (in a cohort aged 15 and older) and data obtained during the ESPAD project "European School Survey Projection Alcohol and Other Drugs" [1-3]. For many years, the ESPAD program has been researching low-alcohol beverages, or “alcopops”, whose consumption is progressively increasing among young students.

The state of the vaginal microbiome in women with hyperproliferative diseases of the uterus under the influence of long-term stress in conditions of military aggression

Thu, 03 Jul 2025 00:00:00 GMT

Название: The state of the vaginal microbiome in women with hyperproliferative diseases of the uterus under the influence of long-term stress in conditions of military aggression Авторы: Горбань, Н.Є.; Трохимович, О.В. Краткий осмотр (реферат): Context. As a result of long-term stress, military aggression has a negative effect on women’s reproductive health. Vaginal microbi ota plays a key role in women’s health and reproduction. Objective. To investigate and analyze the species and quantitative composition of the vaginal microflora in women with hyperpro liferative diseases of the uterus in conditions of military' aggression. Methods. To assess the species and quantitative composition of the vaginal microflora in woman, bacteriological studies were conducted. Patients. Were examined: 1 group - 30 women who were in the occupied territories: 2 group - 30 women who were under the influ ence of the factors of the military conflict (Kyiv city and Kyiv region); 3 group - 30 internally displaced women during the military conflict. The control group consisted of 30 healthy woman. Results. In patients of all examined groups there was no difference in the frequency of detection of sexually transmitted infections: Chlamydia trachomatis 10.0-13.3%; Ureaplasma urealyticum 13.3-30.0%; Mycoplasma hominis 10-30%. In group 1, bacterial vagi nosis was diagnosed in 43.3%. The frequency of sowing enterobacteria was 10.0-16.7%, gram-positive cocci 13.3-20.0%, increased Candida albicans contamination was determined up to 20.0%. Lactobacillus deficiency was found in 76.7% of those examined. In group 2, bacterial vaginosis was diagnosed in 10%. Vaginosis-associated microflora 10.0-16.7%, gram-positive cocci with pathogenic properties and enterobacteria with pathogenic properties were determined as part of bacterial associations, respectively 10.0-13.3% and 6.7-10.0%. The frequency of sowing Candida albicans was 13.3%. Lactobacillus deficiency was established at 6.7%. In group 3, contamination of the vagina with enterobacteria with pathogenic properties was detected in 10.0-13.3%, gram-positive cocci with pathogenic properties 16.7-20,0%. Candida albicans was detected in up to 13.3%. The frequency of diagnosis of bacterial vaginosis was 26.7%. Deficiency of lactobacilli was established in 73.3%. Conclusions. The obtained data established a negative effect of long-term stress on the condition of the vaginal microbiome of women with hyperproliferative diseases of the uterus in conditions of military’ aggression.

Experience of using modern oral iron formulations for the correction of iron deficiency conditions in women of reproductive age

Mon, 19 Jan 2026 00:00:00 GMT

Название: Experience of using modern oral iron formulations for the correction of iron deficiency conditions in women of reproductive age Авторы: Кондратюк, В.К.; Нікітіна, І.М.; Горбань, Н.Є.; Кондратюк, К.О.; Дзись, Н.П. Краткий осмотр (реферат): Aim: To scientifically justify the use of the FERRO-EURIKA™ food supplement as a corrective agent for iron deficiency (ID) in women of reproductive age. Materials and Methods: The study involved 120 women aged 18 to 35 years (median age: 29 years; interquartile range: 24–33 years) with laboratory-con- firmed iron deficiency (ID) and iron deficiency anaemia (IDA) related to chronic blood loss (ICD-10 N 92.0 – Excessive and frequent menstruation with regular cycles). In addition to evaluating changes in peripheral blood parameters and iron stores, we analysed the participants’ complaints and clinical manifestations of iron deficiency conditions (sideropenic and anaemic syndromes). All subjects were divided into two representative groups of 60 women each. Women of Group 1 (main group, n = 60) received iron bisglycinate 157 mg (equivalent to 30 mg of elemental bivalent iron) in combination with glucosamine salt of (6S)-5-methyltetrahydrofolate – 740 µg (equivalent to 400 µg of folic acid), one capsule twice daily, 30 minutes before meals, for pathogenetically justified correction of ID conditions. Women of Group 2 (comparison group, n = 60) received ferrous sulfate 247.25 mg (equivalent to 80 mg of elemental bivalent iron), one capsule twice daily, 30 minutes before meals. The treatment duration for both groups was 90 days. Results: We analysed clinical manifestations of iron deficiency conditions and laboratory parameters in women of reproductive age both before the initiation of iron therapy and during correction (on Days 21, 60, and 90 of treatment). Dynamic analysis of clinical symptoms and haematologic indicators in both groups demonstrated a significant decrease in subjective complaints, accompanied by normalization of laboratory parameters, confirming the positive effects of the interventions. Safety and tolerability analyses of the correction of ID conditions were performed to evaluate adherence to long-term iron supplementation among women. An analysis of the causes of treatment discontinuation revealed gastrointestinal adverse effects associated with iron intake: nausea occurred in 5 (8.3%) women of Group 1 and 13 (24.1%) of Group 2; constipation in 2 (3.3%) of Group 1 and 7 (13.0%) of Group 2; and abdominal pain in 2 (3.3%) of Group 1 and 9 (16.7%) of Group 2. These complaints in Group 1 were mild in intensity and resolved by Day 60, allowing all participants in this group to successfully complete the full treatment course. In contrast, gastrointestinal symptoms persisted in Group 2 at Days 60 and 90, resulting in reduced adherence to therapy, with approximately 30% of patients discontinuing further intake of the prescribed iron preparation. Conclusions: 1. The results of the study indicate that the FERRO-EURIKA™ food supplement may be an effective oral agent for correcting iron deficiency conditions in women of reproductive age. 2. The combination of iron bisglycinate and glucosamine salt of (6S)-5-methyltetrahydrofolate in the composition of FERRO-EURIKA™ contributes to the normalization of haematologic parameters, even at lower doses of iron compared to standard formulations.3. Women who received the FERRO-EURIKA™ food supplement demonstrated better tolerability and a lower incidence of gastrointestinal adverse effects, leading to higher adherence to therapy and successful completion of the treatment course.